Research reveals new pathways related to fear memory — science and technology-luonv

The research reveals the fear memory related new neural pathways — science and technology — people.com.cn original title: research reveals the fear memory related new neural pathways in the newspaper news (reporter Huang Xin) Shanghai Institute of life science research group Muming Pu nerve a new neural pathways of fear found in mice. Related research papers published online September 5th in nature neuroscience. In auditory conditioned fear learning, the mouse first heard a sound and was given a foot shock. The mouse is associated with the sound and the electric shock, and when it comes to the sound of fear. Based on the conditions of neural circuits of fear, it is generally believed that the afferent auditory information from the auditory thalamus and cortex, thalamus, amygdala and then through auditory and auditory cortex, amygdala pathway in the amygdala and the shock of information integration from the somatosensory cortex. However, in this study, using a combination of fluorescence labeling, virus tracing, and immunoelectron microscopy, the researchers found a new projection pathway: the lateral amygdala, the auditory cortex. Using chemical genetic and genetic techniques, the researchers found that selective inhibition of neuronal activity in this pathway significantly reduced the fear response in mice, suggesting that this pathway plays a key role in fear memory. In vivo imaging of the auditory cortex in mice using two-photon imaging. It was found that the dendritic spines in the apical amygdaloid nucleus and the apical dendrites of the fifth layers of the auditory cortex were significantly increased after fear learning for 3 days. At the same time, the researchers found that after fear learning, the proportion of the axon and dendritic spines in the lateral amygdala auditory cortex was much higher than the average. The researchers also found that the vast majority of newly formed synapses are formed by the addition of new synaptic structures in the existing synaptic structures. (commissioning editor Wei Yan and Zhao Zhuqing)相关的主题文章: